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Kidney Cancer

The most common type of kidney cancer is renal cell carcinoma (RCC), formerly called hypernephroma, while carcinoma of the ureter and the renal pelvis are less prevalent.

Aside from operations and if applicable, radiation therapy, conventional chemotherapy only plays a minor role in treatment choices. Targeted therapies with angiogenesis inhibitors, which inhibit the growth of new blood vessels, make it impossible for new blood vessels to grow in the tumor. Other drugs block growth signals in the tumor cells: they inhibit important enzymes, the so-called tyrosine kinases. Additionally, antibodies that target specific characteristics of the tumor have been developed.

Immunotherapy is and has been of increased importance in treating kidney cancer, for instance with the use of cytokines, which function as the immune system’s messengers. Other innovative therapeutic approaches are currently being tested in clinical trials and in the framework of compassionate use.

More than 20.000 genes determine the tumor-biological behavior (growth rate, aggression, metastasis, response to treatment) of any given tumor, yet only a few find consideration in conventional cancer treatment selection.

From a floating iceberg less than 20% is visible on the surface. In contrast, the percentage of treatment-relevant tumor genes routinely recognized by the oncologist is only a few in a thousand.

Clinically important innovative assays for kidney cancer

NextGen Oncology offers a wide range of cutting-edge genetic analyses to uncover clinically relevant features of the individual tumor. These innovative methods offer oncologists an in-depth look at the tumor biology/genetics, thus paving the way to a personalized cancer treatment.

Our PANTHER Test makes an important contribution to an individualized tumor treatment as it provides a comprehensive analysis of clinically useful gene activity patterns. PANTHER comprises a complete gene expression chip transcriptome analysis augmented with immunohistochemical analyses and  quantitative PCR analyses of genes with key functions in clinically important signal transduction pathways.

Various Gene Mutation Panels uncover genetic variations for a personalized targeted treatment in the context of precision oncology.

Our highly recommended ELE.PHANT Assay  is a start-of-the-art contribution to a personalized treatment by precision oncology.

By Liquid Biopsy (LINK) a tumor and the treatment tailored to it can be assessed without having to undergo an invasive tumor tissue biopsy. A mere blood sample is enough. Circulating tumor cells (CTCs) or circulating cell-free tumor DNA (cftDNA) form the analytical basis of liquid biopsy. NextGen Oncology offers sensitive technologies for the determination of circulating tumor cells (CTCs) in the peripheral blood for estimation of the tumor burden and even more important for treatment response monitoring.

In this context, an analysis of the mutation spectrum of circulating free tumor DNA (cfDNA) in the patient’s blood plasma enables the monitoring of the response to a treatment with mutation-specific drugs. This test is of particular clinical importance since tumors treated with targeted therapy often change their mutational pattern within several months. If this happens, they no longer respond to the current therapy.

Cytotoxic treatment offers uncertain prospects of success while severely limiting a patient’s quality of life. Our chemosensitivity tests move away from the trial and error principle of conventional cytotoxic treatment. A prediction of response to a great variety of cytotoxic drugs and natural compounds is the focus of these tests.

Histological appearance of renal cell carcinoma

Cancer Vaccine development

In recent years, a deeper insight into the complex tumor immunology as well as the availability of new genetic tools have promoted the development of vaccine-based cancer immunotherapy.

These innovations in developing individual vaccines are bringing the dream of personalized, highly specific and gentle cancer therapy closer to realization. NextGen Oncology is focused on the design of personalized cancer vaccines based on the individual mutation pattern of the patient, so-called mutated neoantigen peptide vaccines.

Deep freezing of tumor tissue (Cryopreservation)

The standard procedure for the storage of tumor tissue involves formalin fixation and embedding of the fixed tissue in paraffin blocks (FFPE blocks). The quality of FFPE block tissue is quit often impaired by various formalin-fixation related artefacts. This can undoubtedly be a serious drawback for present and future analytical procedures. Keeping this in mind, it can be of critical importance to have higher quality tumor tissue at hand. Deep-freezing (cryopreservation) of the tumor tissue is the solution. Uomorphis as part of the NextGen Oncology Group offers such cryopreservation, either as standard preservation frozen in the gas phase of liquid nitrogen at a temperature of under -190°C or as LIFE cryopreservation, in which the tumor cells are isolated and frozen alive in a computer-controlled specialized medium.

To determine the best and most promising course of action in your case, you are very welcome to contact MUDr. Luzbetak for a personal consultation.

We are happy to consult you in finding the right treatment for Kidney Cancer!

Testing Methods for Kidney Cancer


PANTHER measures the activity of all human genes (transcriptome). Based on numerous published gene expression signatures, PANTHER provides the treating oncologist with a wealth of valuable information for personalized therapeutic decisions.

Elephant Assay

ELE.PHANT, indispensable for an individualized comprehensive precision oncology treatment, is a unique state-of-the-art assay amalgamating the patient’s transcriptome data (PANTHER) and therapeutically important mutation data derived from Gen Mutation Panels.

zirkulierende Tumor DNA

Circulating Tumor DNA

Circulating tumor DNA (cfDNA) represents an accurate reflection of a tumor’s mutation pattern in the blood plasma. It is mostly used for real-time response monitoring to targeted drug treatment and as a surrogate analysis of a tumor’s mutational status in cases where no tumor tissue is accessible.

CTC circulating tumor cells

Zirkulierende Tumorzellen (CTC)

Der Test dient der Bestimmung der Belastung des Blutes durch Tumorzellen. Er erlaubt eine molekulargenetische Charakterisierung der Tumorerkrankung (Real-time liquid biopsy).

Chemo-/Biopharmaceutical Sensitivity

Using isolated, living tumor cells, this test determines the response to cytotoxic and biopharmaceutical treatments.