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Epigallocatechin Gallate (EGCG) in cancers.

Epigallocatechin Gallate (EGCG) in cancers.

EGCG is a substance extracted from green tea and represents up to 30% of its dry mass. The tea plant has been used in China for at least 6000 years and is one of Asia’s most important everyday drinks. In opposition to black tea, oxidation, i.e., the decomposition of the leaves by oxygen, is prevented during the drying process by roasting, steaming, or brief heating. Thus, almost all the ingredients of the fresh plant are preserved.

From a chemical point Continue reading

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Could the analysis of tumor cells from the blood predict the therapeutic outcome and challenge previous treatment methods?

Could the analysis of tumor cells from the blood predict the therapeutic outcome and challenge previous treatment methods?

Significance of tumor cells circulating in the blood

The development of targeted cancer therapies is being pursued in many studies, and research on tyrosine kinase inhibitors as well as immune checkpoint inhibitors is becoming increasingly important. However, cytotoxic chemotherapeutic agents remain the gold standard in neo-adjuvant or adjuvant treatment of tumors at various stages. The choice for mono- or combination therapy is often guideline-based without any molecular or functional indication, reflecting the limitations of such non-personalized therapies. For the treatment Continue reading

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Dostarlimab in MSI-H/dMMR colorectal cancer

Dostarlimab in MSI-H/dMMR colorectal cancer

The results of a recent study published in the New England Journal of Medicine, PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer, aroused astonishment worldwide. The reason is that a complete response to therapy was achieved in all patients treated with the PD-1 blocker dostarlimab in the trial. Also, within the follow-up period (between 6 and 25 months, magnetic resonance imaging (MRI) and endoscopic examinations could not detect any recurrence or progression. [1]

Study Objective and Methods

The Continue reading

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